No Gut Supplement is a Cure-All

They must be combined — to make a major difference.

My health progress would not be possible without combining the best gut supplements over time.

Why Take Gut Supplements?

To restore poor gut health, food alone was never sufficient for me — nor for most of the thousands of people I’ve spoken to over the years.

For many, neither is nutritional therapy, hormone therapy, improving the metabolic rate, or strict mold avoidance. None alone are sufficient to restore gut health.

What we’ve observed is that, often, something powerful needs to enter the gut — and actually change the microbiome for the better.

Gut Health is Never Static

It’s important to really understand this: the gut microbiome is always changing, throughout life.

It’s always reacting to food, stress, and pathogens bombarding it. Unfortunately, most stressors — especially the chronic stressors of modern — have the effect of harming the gut microbiome over time. Weakening gut health is likely in everyone’s future — unless we do something about it.

Just like the seasons come and go, our gut responds to the challenges and variations of daily life.

Therefore, we need a long-term strategy to 1) recover our robust gut health and then 2) protect it — to prevent what’s otherwise inevitable: continually-worsening gut health as we age.



The Gut Should Be Hostile
to Microbes

The human body is bombarded with microbes all day — every day.

In fact, the average person swallows over a trillion microbes each day.

A Healthy Body Keeps All Microbes in Check

In robust health, the body can regulate the microbes in the gut, keeping them from becoming “too comfortable” and growing out of control.

Most microbes are killed by high stomach acid. The few that survive find the upper intestines a difficult place to live — high in IgA and antimicrobial peptides known as Paneth cells.

Lower in the gut, the colon is full of macrophages, eosinophils, and mast cells. Using these weapons, the cells of the larger intestine can “phagocytose pathogens and release toxic and inflammatory mediators such as nitrogen radicals and histamine.”

The immune system is constantly on the hunt for microbes — making life difficult for any would-be invader.

“A huge proportion of your immune system is actually in your GI tract.

The immune system is inside your body, and the bacteria are outside your body.”

Dan Peterson, Johns Hopkins University School of Medicine

A Weak Body Struggles Against Microbes

On the other hand, when health is weaker, the body’s immune system cannot adequately oppose the rising tide of microbial bombardment.

The gut’s semi-permeable barrier weakens and pathogens enter the bloodstream, setting off an endless immune response — inflammation, histamine, and mast cell activation.

Rising levels of pathogens throughout the body — above and beyond what the immune system can control — cause the body to be in a perpetual state of stress, and therefore, unable to execute normal metabolic and hormonal functions.

As you well know from being ill, an activated immune response is misery. If your immune response is overactive, each day can be miserable.

The Purpose of a Gut Protocol

A smart gut regimen “helps out” the gut by beating back the pathogens and overactive gut flora that have made themselves at home.

With a little help, the body can begin to re-establish its own control of the situation.

As the digestive process begins to improve, nutrients are better absorbed and energy production rises — both of which boost immunity.

Then, as the immune system strengthens:

  • Pathogens are inherently kept in check
  • Inflammation levels fall
  • Hormone levels, long-suppressed due to inflammation and infection, can begin to balance, leading to restored normal function of the metabolic, sexual, and circadian systems.

Brain health, sleep, energy levels all improve when digestive health and immunity are restored.

Not An Overnight Process

This happens over time.

When we are always “helping out” the immune system, “beating back” pathogens, and repopulating the gut with good microbes — throughout the day — we give the body a chance to strengthen, little by little.

This absolutely requires long-term effort. How long?

You can notice benefits within weeks and even days. But the improvements will be temporary unless you continue supporting your gut.

Restoring gut health, especially when it’s really struggling, isn’t a 5-Day Challenge. It’s months of stacking the deck, over and over and over, in your body’s favor.

So, Increase Hostility

When the immune system is weak, the gut becomes a warm, alkaline, moist place — with a lot of decaying food matter. A perfect place for microbes to live and grow.

Without the immune system, the gut is an ideal home for any and all microbial life.

Don’t let microbes feel at home in your gut. If they are comfortable, something is wrong.

Therefore, the main goal here is to increase the hostility of your gut to pathogens — something that all gut supplements actually do.


OVERVIEW: The Gut Supplements

As we’ve said, all gut supplements increase hostility (to pathogens) in the gut — in some way, shape, or form.

For instance, antimicrobials “kill” microbes. Probiotics literally “fight” bad microbes. Prebiotics increase hostility indirectly, by feeding good microbes selectively, thereby reducing populations of pathogens.

Three Types of Gut Supplement

As we’ve discussed in Supplement Timing, gut supplements are either killing or repopulating.

A third group sits in between: balanced supplements, which have antimicrobial properties and encourage probiotics.



Tend to Kill All or Some Microbes.
  • Herbs (extracts & oils
  • Enzymes
  • Minerals
  • Apple Cider Vinegar
  • Monolaurin
  • Fulvic Acid



Tend to Kill the Bad & Feed the Good Microbes.
  • Colostrum
  • *Bee Products*
  • Turkey Tail
  • (Fulvic Acid)



Selectively Feed or Introduce Good Microbes.
  • Probiotics
  • Prebiotics

*Fulvic Acid* is a moderate-strength antimicrobial,
and only a very, very weak repopulator.

Antimicrobials (“Killers”)

Gut supplements which “kill” microbes are natural antibiotics.

Often these compounds attack the cell walls of microbes, killing them, or are simply toxic to microbes.

  • Ex: Herbal extracts & oils, enzymes, compounds in bee products, some fatty-acids.


Probiotics are microbes beneficial to human gut health (or microbiomes elsewhere in the body such as the skin, mouth, nose, or vagina).

Probiotics release nutrients and nutrient-like chemicals when they ferment food in the gut.

They also attack other microbes — which means they can behave as antibiotics, actively killing and suppressing pathogens in the gut.

  • Ex: Bifido, Lactobacillus, and many other strains of bacteria


The fibers that feed beneficial microbes are known as prebiotics.

Most of their benefit comes from enhancing the numbers of probiotics in your gut.

Unfortunately, prebiotics can feed pathogens in some situations — particulary when dysbiosis is severe, and especially when prebiotic doses are too high — but prebiotics generally resist fermentation by bad microbes.

  • Ex: Apple pectin, FOS, GOS, XOS, chicory root (inulin)

Begin Slow

Your first weeks of taking a new *gut* supplement will tell you 90% of what you need to know about that supplement. Don’t waste this valuable time.

*This is not true about nutritional supplements, but with gut supplements, the first weeks are critical for your awareness.

If you’ve had much trouble with gut health, it’s imperative to begin with baby steps.

After all, No gut supplement is guaranteed to:
  1. Work
  2. Make you feel better
  3. Be safe for you

Further, the more powerful a supplement is, the more likely it is to disrupt your flora. Though disruption is needed for change, too much could be too uncomfortable, or overwhelm a fragile system.

BEGIN: Always With One Single Supplement

The most important baby step? Start with a single supplement, with only one dose.

Starting with one single product allows you to verify how the supplement affects you — if at all.

Knowing how one ingredient or product affects you is invaluable — it’s the difference between improving and being stuck for years.

It cannot be overstated how important and beneficial it is to focus on single ingredients and supplements at a time.

DISOMFORT? How to Reduce a Supplement’s Intensity

If a supplement causes some discomfort, or otherwise feels too intense, consider two ways to reduce its impact.

#1 — Open a capsule and split the dose into a smaller amount.
  • If a powder, use less than one scoop — potentially much less.
#2 — Take with, or prior to a meal.
  • Food will dilute the compound. Take up to 15 minutes before or after a meal.

Why Does Discomfort Happen?

Some discomfort may be inevitable. It could reflect disrupting and disturbing microbes in your gut — something that needs to happen for your gut microbiome to improve.

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